Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis

Immunity to Mycobacterium tuberculosis

1Department of Infectious Diseases and Immunology, University of Sydney, Sydney, NSW 2000, Australia 2 Infectiologie Animale et Santé Publique, INRA Centre de Tours, Nouzilly 37380, France 3Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA 4Centenary Institute of Cancer Medicine and Cell Biology, Newto...

Innate immunity to Mycobacterium tuberculosis.

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance between the bacillus and host defense mechanisms. Traditionally, protective immunity to tuberculosis has been ascribed to T-cell-mediated immunity, with CD4(+) T cells playing a crucial role. Recent immunological and genetic studies support the long-standing notion that innate immunity is also relevant...

Macrophage response to Mycobacterium tuberculosis infection.

The immune response to Mycobacterium tuberculosis (Mtb) infection is the formation of multicellular lesions, or granolomas, in the lung of the individual. However, the structure of the granulomas and the spatial distribution of the immune cells within is not well understood. In this paper we develop a mathematical model investigating the early and initial immune response to Mtb. The model consi...

Macrophage receptors for Mycobacterium tuberculosis.

Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.

In humans and in mice, control of the intracellular pathogen, Mycobacterium tuberculosis (Mtb), requires IFN-gamma. Although the adaptive immune response results in production of substantial amounts of IFN-gamma in response to Mtb, the immune response is unable to eradicate the infection in most cases. We have previously reported evidence that Mtb inhibits macrophage responses to IFN-gamma, sug...